Guangtao Zhang: Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - pocketboek
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths… Meer...
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal. 160 pp. Englisch, Books<
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival… Meer...
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator / Taschenbuch für 58.99 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (kartoniert) Hardcover;Naturwissenschaften, Medizin, Informatik, Technik;Organische Chemie, VDM Verlag Dr. Müller<
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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulat… Meer...
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator. Aus dem Bereich: Bücher, Wissenschaft, Chemie, Medien > Bücher, VDM Verlag Dr. Müller<
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Zhang, Guangtao: Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and ?-Helix Mimetics as Modulators of Dormancy Survival Regulator - pocketboek
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - pocketboek
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths… Meer...
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal. 160 pp. Englisch, Books<
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival… Meer...
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator / Taschenbuch für 58.99 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (kartoniert) Hardcover;Naturwissenschaften, Medizin, Informatik, Technik;Organische Chemie, VDM Verlag Dr. Müller<
Verzendingskosten:Shipping in 1-2 weeks, , Versandkostenfrei nach Hause oder Express-Lieferung in Ihre Buchhandlung., DE. (EUR 0.00)
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulat… Meer...
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator. Aus dem Bereich: Bücher, Wissenschaft, Chemie, Medien > Bücher, VDM Verlag Dr. Müller<
Nr. 14550045. Verzendingskosten:, , DE. (EUR 0.00)
Zhang, Guangtao: Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and ?-Helix Mimetics as Modulators of Dormancy Survival Regulator - pocketboek
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Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.
Gedetalleerde informatie over het boek. - Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR
EAN (ISBN-13): 9783639309690 ISBN (ISBN-10): 3639309693 Gebonden uitgave pocket book Verschijningsjaar: 2011 Uitgever: VDM Verlag Dr. Müller
Boek bevindt zich in het datenbestand sinds 2009-07-01T15:06:36+02:00 (Amsterdam) Detailpagina laatst gewijzigd op 2023-06-25T11:07:36+02:00 (Amsterdam) ISBN/EAN: 3639309693
ISBN - alternatieve schrijfwijzen: 3-639-30969-3, 978-3-639-30969-0 alternatieve schrijfwijzen en verwante zoekwoorden: Auteur van het boek: zhang Titel van het boek: synthesis, helix