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Oncogenes and Tumor Suppressor Genes in Human Malignancies - Benz, Christopher C. / Benz, C. C. / Liu, E. T.
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Benz, Christopher C. / Benz, C. C. / Liu, E. T.:
Oncogenes and Tumor Suppressor Genes in Human Malignancies - gebruikt boek

ISBN: 9780792319603

ID: 3166873

This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and management. The remainder of the volume updates molecular mechanisms relating to select growth factor systems, oncogenes, and tumor suppressor genes introduced earlier in the disease-oriented chapters. These reviews convey the increasing fascination that comes with a greater understanding of tumor physiology. They reveal, for instance, that tumor cells can induce the secretion of paracrine growth factors from non-malignant tissues, thus usurping normal genetic programs reserved for fetal development or wound healing such as those that provide neovascularization for a malignant tissue colony. The uncovering of these subverted intercellular mechanisms, as well as the constitutively stimulated intracellular signaling pathways associated with activated oncogenes and mutated tumor suppressor genes, provide researchers with many new targets for the development of more specific and less toxic anticancer agents. A number ofthese novel gents are already in clinical test. Oncogenes and Tumor Suppressor Genes in Human Malignancies Benz, Christopher C. / Benz, C. C. / Liu, E. T., Springer

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Oncogenes and Tumor Suppressor Genes in Human Malignancies
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Oncogenes and Tumor Suppressor Genes in Human Malignancies - nieuw boek

ISBN: 0792319605

ID: 3-13452176

This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and management. The remainder of the volume updates molecular mechanisms relating to select growth factor systems, oncogenes, and tumor suppressor genes introduced earlier in the disease-oriented chapters. These reviews convey the increasing fascination that comes with a greater understanding of tumor physiology. They reveal, for instance, that tumor cells can induce the secretion of paracrine growth factors from non-malignant tissues, thus usurping normal genetic programs reserved for fetal development or wound healing such as those that provide neovascularization for a malignant tissue colony. The uncovering of these subverted intercellular mechanisms, as well as the constitutively stimulated intracellular signaling pathways associated with activated oncogenes and mutated tumor suppressor genes, provide researchers with many new targets for the development of more specific and less toxic anticancer agents. A number of these novel gents are already in clinical test. Livre - Livre, [PU: Kluwer Academic Publishers]

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Oncogenes and Tumor Suppressor Genes in Human Malignancies - Benz, C.C. / Liu, E.T. (eds.)
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Benz, C.C. / Liu, E.T. (eds.):
Oncogenes and Tumor Suppressor Genes in Human Malignancies - gebonden uitgave, pocketboek

ISBN: 9780792319603

[ED: Hardcover], [PU: Springer, Berlin], The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage ment. xvii, 382 S. XVII, 382 p. 235 mm Versandfertig in über 4 Wochen, [SC: 0.00], Neuware, gewerbliches Angebot

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Oncogenes and Tumor Suppressor Genes in Human Malignancies (Cancer Treatment and Research) - Christopher Benz; E.T. Liu
(*)
Christopher Benz; E.T. Liu:
Oncogenes and Tumor Suppressor Genes in Human Malignancies (Cancer Treatment and Research) - gebruikt boek

1989, ISBN: 0792319605

ID: 5767294

The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features clinical,internal medicine,medical books,medicine,medicine and health sciences,oncology,textbooks Clinical, Springer

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Oncogenes and Tumor Suppressor Genes in Human Malignancies - Christopher C. Benz; E. T. Liu
(*)
Christopher C. Benz; E. T. Liu:
Oncogenes and Tumor Suppressor Genes in Human Malignancies - gebonden uitgave, pocketboek

1993, ISBN: 9780792319603

ID: 607661

1993 ed., Hardcover, Buch, [PU: Springer]

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Bijzonderheden over het boek
Oncogenes and Tumor Suppressor Genes in Human Malignancies

This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and management. The remainder of the volume updates molecular mechanisms relating to select growth factor systems, oncogenes, and tumor suppressor genes introduced earlier in the disease-oriented chapters. These reviews convey the increasing fascination that comes with a greater understanding of tumor physiology. They reveal, for instance, that tumor cells can induce the secretion of paracrine growth factors from non-malignant tissues, thus usurping normal genetic programs reserved for fetal development or wound healing such as those that provide neovascularization for a malignant tissue colony. The uncovering of these subverted intercellular mechanisms, as well as the constitutively stimulated intracellular signaling pathways associated with activated oncogenes and mutated tumor suppressor genes, provide researchers with many new targets for the development of more specific and less toxic anticancer agents. A number of these novel gents are already in clinical test.

Gedetalleerde informatie over het boek. - Oncogenes and Tumor Suppressor Genes in Human Malignancies


EAN (ISBN-13): 9780792319603
ISBN (ISBN-10): 0792319605
Gebonden uitgave
Verschijningsjaar: 1993
Uitgever: Springer
384 Bladzijden
Gewicht: 0,739 kg
Taal: eng/Englisch

Boek bevindt zich in het datenbestand sinds 2008-11-17T22:29:50+01:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2019-08-17T22:46:52+02:00 (Amsterdam)
ISBN/EAN: 0792319605

ISBN - alternatieve schrijfwijzen:
0-7923-1960-5, 978-0-7923-1960-3


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