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Oncogenes and Tumor Suppressor Genes in Human Malignancies
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ISBN: 9780792319603

This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function geneti… Meer...

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Oncogenes and Tumor Suppressor Genes in Human Malignancies - Christopher Benz; E.T. Liu
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Oncogenes and Tumor Suppressor Genes in Human Malignancies - gebonden uitgave, pocketboek

ISBN: 9780792319603

The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the n… Meer...

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Christopher Benz; E.T. Liu:
Oncogenes and Tumor Suppressor Genes in Human Malignancies - gebonden uitgave, pocketboek

ISBN: 9780792319603

The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the n… Meer...

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Oncogenes and Tumor Suppressor Genes in Human Malignancies - Christopher C. Benz
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Christopher C. Benz:
Oncogenes and Tumor Suppressor Genes in Human Malignancies - gebonden uitgave, pocketboek

ISBN: 9780792319603

Hardback, [PU: Springer], The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic mali… Meer...

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Oncogenes and Tumor Suppressor Genes in Human Malignancies (Cancer Treatment and Research) - Benz, Christopher and E.T. Liu
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Benz, Christopher and E.T. Liu:
Oncogenes and Tumor Suppressor Genes in Human Malignancies (Cancer Treatment and Research) - gebonden uitgave, pocketboek

1993, ISBN: 0792319605

Auflage: 1993 23,4 x 15,6 x 2,4 cm, Gebundene Ausgabe 382 Seiten Gebundene Ausgabe ex Library Book / aus einer wissenschafltichen Bibliothek / 2, [PU:Springer,]

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Oncogenes and Tumor Suppressor Genes in Human Malignancies

This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and management. The remainder of the volume updates molecular mechanisms relating to select growth factor systems, oncogenes, and tumor suppressor genes introduced earlier in the disease-oriented chapters. These reviews convey the increasing fascination that comes with a greater understanding of tumor physiology. They reveal, for instance, that tumor cells can induce the secretion of paracrine growth factors from non-malignant tissues, thus usurping normal genetic programs reserved for fetal development or wound healing such as those that provide neovascularization for a malignant tissue colony. The uncovering of these subverted intercellular mechanisms, as well as the constitutively stimulated intracellular signaling pathways associated with activated oncogenes and mutated tumor suppressor genes, provide researchers with many new targets for the development of more specific and less toxic anticancer agents. A number of these novel gents are already in clinical test.

Gedetalleerde informatie over het boek. - Oncogenes and Tumor Suppressor Genes in Human Malignancies


EAN (ISBN-13): 9780792319603
ISBN (ISBN-10): 0792319605
Gebonden uitgave
Verschijningsjaar: 1993
Uitgever: Springer
384 Bladzijden
Gewicht: 0,739 kg
Taal: eng/Englisch

Boek bevindt zich in het datenbestand sinds 2008-11-17T22:29:50+01:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2022-11-01T08:44:46+01:00 (Amsterdam)
ISBN/EAN: 0792319605

ISBN - alternatieve schrijfwijzen:
0-7923-1960-5, 978-0-7923-1960-3
alternatieve schrijfwijzen en verwante zoekwoorden:
Auteur van het boek: benz, springer
Titel van het boek: oncogene, genes


Gegevens van de uitgever

Auteur: Christopher Benz; E.T. Liu
Titel: Cancer Treatment and Research; Oncogenes and Tumor Suppressor Genes in Human Malignancies
Uitgeverij: Springer; Springer US
382 Bladzijden
Verschijningsjaar: 1993-02-28
New York; NY; US
Gewicht: 1,640 kg
Taal: Engels
213,99 € (DE)
219,99 € (AT)
236,00 CHF (CH)
POD
XVII, 382 p.

BB; Oncology; Hardcover, Softcover / Medizin/Klinische Fächer; Onkologie; Verstehen; DNA; angiogenesis; cell; metastasis; tumor; tumorigenesis; Cancer Research; Oncology; Cancer Biology; BC; EA

Preface. 1. Oncogenes and Tumor Suppressor Genes; E. Liu, B. Weissman. 2. Activated Oncogenes and Putative Tumor Suppressor Genes involved in Human Breast Cancers; D. Tripathy, C. Benz. 3. Oncogenes in Human Lung Cancer; R.A. Kratzke, E. Shimizu, F.J. Kaye. 4. Thyroid Growth Factors and Oncogenes; O. Clark, Q.-Y. Duh. 5. Growth Regulation of Human Neuroblastoma; O. El-Badney, M. Israel. 6. Kaposi's Sarcoma: a Cytokine Responsive Neoplasia? S. Miles. 7. BCL-2: Physiology and Role in Neoplasia; A. Bagg, J. Cossman. 8. Malignant Transformation by abl and BCR/ABL; R. van Etten. 9. The Biological and Clinical Role of Increased Insulin Receptors in Human Breast Cancer; R. Vigneri, I. Goldfine. 10. The Role of Fibroblast Growth Factors and Related Oncogenes in Tumor Growth; H. Brem, M. Klagsbrun. 11. Transforming Growth Factor-alpha and its Role in Neoplastic Progression; D. Lee, N.C. Luetteke, L.A. Petch. 12. Growth Regulation by Transforming Growth Factor-beta; B. Arrick, R. Derynck. 13. Signal Transduction by Receptor Tyrosine Kinases; D. Kaplan, D. Morrison. 14. Involvement of G-Proteins, Cytoplasmic Calcium, Phospholipases, Phospholipid-derived Second Messengers, and Protein Kinases in Signal Transduction from Mitogenic Cell Surface Receptors; R. Frye. 15. Fos and Jun Inducible Transcription Factors Regulating Growth of Normal and Transformed Cells; J. Holt. 16. DNA Binding by the Myc Oncoproteins; G.J. Kato, D.W. Wechsler, C.V. Dang. 17. Normal and Malignant Growth Control by p53; C. Finlay 18. Nucleoside Diphosphate Kinases, nm23 and Tumor Metastasis: Possible Biochemical Mechanisms;A. Golden, M. Benedict, A. Shearn. N.Kimura, A. Leone, L. Liotta P. Steeg 19. Angiogenesis: a Mechanism by which Oncogenes Regulate Tumorigenesis; N. Bouck. Index.

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Laatste soortgelijke boek:
9781461530886 Oncogenes and Tumor Suppressor Genes in Human Malignancies (Christopher Benz; E.T. Liu)


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