Drug Metabolism - nieuw boek

EAN (ISBN-13): 9781402041426
ISBN (ISBN-10): 140204142X
Verschijningsjaar: 2006
Uitgever: Springer Netherlands
420 Bladzijden
Taal: eng/Englisch

Boek bevindt zich in het datenbestand sinds 2008-07-14T09:25:33+02:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2023-09-28T14:13:19+02:00 (Amsterdam)
ISBN/EAN: 9781402041426

ISBN - alternatieve schrijfwijzen:
1-4020-4142-X, 978-1-4020-4142-6
alternatieve schrijfwijzen en verwante zoekwoorden:
Auteur van het boek: corina, nae ionescu
Titel van het boek: metabolism

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Gegevens van de uitgever

Auteur: Mino R. Caira; Corina Ionescu
Titel: Drug Metabolism - Current Concepts
Uitgeverij: Springer; Springer Netherland
422 Bladzijden
Verschijningsjaar: 2006-07-10
Dordrecht; NL
Taal: Engels
213,99 € (DE)
220,00 € (AT)
236,00 CHF (CH)
Available
XIV, 422 p.

EA; E107; eBook; Nonbooks, PBS / Medizin/Nichtklinische Fächer; Medizinische Forschung; Verstehen; Oxidation; adverse reactions; biochemistry; chemistry; distribution; drug; drug research; genetics; hydrolysis; medicinal chemistry; metabolism; pharmacokinetics; pharmacology; pharmacy; research; B; Biomedical Research; Pharmacy; Medicinal Chemistry; Pharmacology; Biomedical and Life Sciences; Pharmazie, Apotheke; Medizinische Chemie, Pharmazeutische Chemie; Pharmakologie; BC

Drug Metabolism: Current Concepts Corina Ionescu and Mino R Caira Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. The book includes chapters on ADME (drug absorption, distribution, metabolism and elimination) Pathways of biotransformation (Phase I and Phase II metabolic reactions) Enzymatic systems involved in biotransformation Induction and inhibition of drug-metabolising enzymes Factors that influence drug biotransformation The role of pharmacogenetics Drug-drug interactions and adverse reactions Strategies for drug design.   This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Includes an extensive tabulation of drug-drug interactions and a section dealing with the relatively new topic of pharmacogenetics, as it relates to drug metabolism. Emphasises the importance of metabolism throughout the lifetime of the drug development process, bringing together chemical design and optimisation with eventual clinical use. Includes many more types of metabolic reactions and interactions than existing publications. An emphasis on the understanding of the topics at the molecular level. Avoids details of chemical methodology, allowing the reader to focus on the concepts underlying drug delivery optimisation through a knowledge of the principles of biotransformation. Provides a new, detailed and accessible presentation of drug-drug interactions and adverse reactions at the molecular level. Systematically outlines modern strategies in drug design based primarily on metabolic considerations. The treatment of drug design is more comprehensive than previous coverage as it covers all aspects and implications of drug metabolism the authors consider relevant to the target