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Peptide Research Protocols: Endothelin - Janet J. Maguire, Anthony P. Davenport
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Janet J. Maguire, Anthony P. Davenport:
Peptide Research Protocols: Endothelin - nieuw boek

ISBN: 9781617372919

Tantalizing new research frontiers are opening in peptide research, where the endothelins constitute an important class of signals that can be manipulated therapeutically to treat cardiovascular disease. In Peptide Research Prools: Endothelin, a panel of multidisciplinary experts describes in detail readily reproducible methods to investigate all aspects of peptide research by focusing on the endothelin system-from its synthesis and metabolism, to its function in health and disease. These methods use state-of-the-art molecular techniques to quantify the expression of mRNA, here using both endothelin receptors and the endothelin-converting enzymes. They show how peptides, precursors, receptors, and synthetic enzymes can be localized and quantified in plasma, culture supernatants, tissue homogenate, and tissue sections using antibodies, and how radioligand binding techniques can provide additional information on receptor characterization. In vitro assays are presented to determine the function of peptides in isolated preparations, to characterize new receptor ligands, and to provide information on the tissue-specific processing of precursor peptides-all in the endothelin system. Several in vivo prools illustrate the role of the endothelin peptides in healthy human individuals and describe animal models that can be used to predict the therapeutic potential of cardiovascular drugs that manipulate endothelin synthesis or function. Authoritative and timely, Peptide Research Prools: Endothelin provides both a comprehensive introduction to endothelin biology and an up-to-date collection of proven techniques and experimental strategies for use in peptide research today. Textbooks New Books ~~ Medicine~~ Pharmacy Peptide-Research-Protocols~~Janet-J-Maguire Springer-Verlag New York, LLC A panel of multidisciplinary experts describes in detail readily reproducible methods to investigate all aspects of the endothelin system from its synthesis and metabolism, to its function in health and disease. Theses methods use state-of-the-art molecular techniques to quantify the expression of mRNA for both endothelin receptors and the endothelin converting enzymes. They show how peptides, precursors, receptors, and synthetic enzymes can be localized and quantified in plasma, culture supernatants, tissue homogenate, and tissue sections using antibodies. Several in vivo protocols illustrate the role of the endothelin peptides in healthy human individuals and describe animal models that can be used to predict the therapeutic potential of cardiovascular drugs that manipulate endothelin synthesis or function.

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Peptide Research Protocols - Herausgegeben von Maguire, Janet J. Davenport, Anthony P.
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Herausgegeben von Maguire, Janet J. Davenport, Anthony P.:
Peptide Research Protocols - pocketboek

2010, ISBN: 9781617372919

[ED: Softcover], [PU: Springer, Berlin], The endothelins are a remarkable family of signaling peptides: molecular biology predicted the existence of their receptors and synthetic enzymes prior to both the identification of the encoded proteins and the synthesis of antagonists and inhibitors for use as pharmacological tools. Although considerable advances have been made, culminating in the design of endothelin antagonists with the- peutic potential in cardiovascular disease, much remains to be discovered. Tantalizingly, new research frontiers are emerging. To support further progress, Peptide Research Protocols: Endothelin encompasses experimental protocols that interrogate all facets of an endogenous mammalian peptide s- tem, from peptide and receptor expression through synthetic pathway to peptide function and potential role in human disease. Chapters describe the use of molecular techniques to quantify the expression of mRNA for both endothelin receptors and the endothelin-converting enzymes. Peptides, precursors, receptors, and synthetic enzymes may be localized and quantified in plasma, culture supernatants, tissue homogenates, and tissue s- tions using antibodies, while additional information on receptor characterization may be obtained using radioligand binding techniques. Several protocols cover in vitro assays that determine the function of the endothelin peptides in isolated preparations, that characterize new endothelin receptor ligands, or provide inf- mation on the tissue-specific processing of endothelin precursor peptides.2010. x, 242 S. 67 SW-Abb., 1 Farbabb. 229 mmVersandfertig in 3-5 Tagen, [SC: 0.00]

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Peptide Research Protocols
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Peptide Research Protocols - nieuw boek

2002, ISBN: 9781617372919

ID: 698653305

Endothelin Methods in Molecular Biology. Softcover reprint of hardcover 1st ed. 2002. Endothelin Methods in Molecular Biology. Softcover reprint of hardcover 1st ed. 2002. Bücher > Wissenschaft > Medizin

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Peptide Research Protocols - Janet J. Maguire; Anthony P. Davenport
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Janet J. Maguire; Anthony P. Davenport:
Peptide Research Protocols - pocketboek

ISBN: 9781617372919

ID: 9781617372919

Pharmacy; Pharmacy Books Book (Paperback Initiative), Springer Science+Business Media

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Peptide Research Protocols - Janet J. Maguire; Anthony P. Davenport
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Janet J. Maguire; Anthony P. Davenport:
Peptide Research Protocols - pocketboek

2010, ISBN: 9781617372919

ID: 16168270

1st ed. Softcover of orig. ed. 2002, Softcover, Buch, [PU: Humana Press Inc.]

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Peptide Research Protocols

A panel of multidisciplinary experts describes in detail readily reproducible methods to investigate all aspects of the endothelin system from its synthesis and metabolism, to its function in health and disease. Theses methods use state-of-the-art molecular techniques to quantify the expression of mRNA for both endothelin receptors and the endothelin converting enzymes. They show how peptides, precursors, receptors, and synthetic enzymes can be localized and quantified in plasma, culture supernatants, tissue homogenate, and tissue sections using antibodies. Several in vivo protocols illustrate the role of the endothelin peptides in healthy human individuals and describe animal models that can be used to predict the therapeutic potential of cardiovascular drugs that manipulate endothelin synthesis or function.

Gedetalleerde informatie over het boek. - Peptide Research Protocols


EAN (ISBN-13): 9781617372919
ISBN (ISBN-10): 1617372919
pocket book
Verschijningsjaar: 2010
Uitgever: Springer-Verlag GmbH
252 Bladzijden
Gewicht: 0,413 kg
Taal: eng/Englisch

Boek bevindt zich in het datenbestand sinds 27.12.2011 17:38:05
Boek voor het laatst gevonden op 03.05.2017 09:57:01
ISBN/EAN: 9781617372919

ISBN - alternatieve schrijfwijzen:
1-61737-291-9, 978-1-61737-291-9


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