2009, ISBN: 3639076303

[EAN: 9783639076301], Neubuch, [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware -Tuberculosis and Cancer are among the mostdevastating and therapeutically challenging dis… Meer...

[EAN: 9783639076301], Neubuch, [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware -Tuberculosis and Cancer are among the mostdevastating and therapeutically challenging diseases.The development of muti-drug resistance in TB causingbacteria, Mycobacterium tuberculosis and cancerouscells has prompted the search for effective novelcompounds. This book focuses on the synthesis and theevaluation of different analogues of diospyrin, aproven anti-TB and anti-cancer agent. A number ofnovel binaphthoquinone and naphthoquinone-naphthalenebiaryl compounds were synthesized by using Suzukimethodology.Several analogues were evaluated for their biologicalactivity against fast growing bacteria viz., M.smegmatis and M. aurum and against a clinical strainof M. tuberculosis. Four novel quinones were alsoevaluated for their ability to induce apoptosis inthree cancer cell lines viz., HeLa, MCF7, MG63 andone normal cell line i.e. CHO by using APOpercentage,DNA fragmentation and Cell cycle assays. Thispreliminary investigation could provoke an interestin scientific community to synthesize otherstructurally modified quinonoids in order to developand establish them as potent drugs againstmycobacterium and cancer. 120 pp. Englisch, Books<

2009, ISBN: 9783639076301

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Tuberculosis and Cancer are among the most devastating and therapeutically challenging diseases. The development of muti-drug resistance in T… Meer...

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Tuberculosis and Cancer are among the most devastating and therapeutically challenging diseases. The development of muti-drug resistance in TB causing bacteria, Mycobacterium tuberculosis and cancerous cells has prompted the search for effective novel compounds. This book focuses on the synthesis and the evaluation of different analogues of diospyrin, a proven anti-TB and anti-cancer agent. A number of novel binaphthoquinone and naphthoquinone-naphthalene biaryl compounds were synthesized by using Suzuki methodology. Several analogues were evaluated for their biological activity against fast growing bacteria viz., M. smegmatis and M. aurum and against a clinical strain of M. tuberculosis. Four novel quinones were also evaluated for their ability to induce apoptosis in three cancer cell lines viz., HeLa, MCF7, MG63 and one normal cell line i.e. CHO by using APOpercentage, DNA fragmentation and Cell cycle assays. This preliminary investigation could provoke an interest in scientific community to synthesize other structurally modified quinonoids in order to develop and establish them as potent drugs against mycobacterium and cancer. 2009. 120 S. 220 mm Versandfertig in 6-10 Tagen, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Offene Rechnung (Vorkasse vorbehalten)<

ISBN: 9783639076301

Tuberculosis and Cancer are among the mostdevastating and therapeutically challenging diseases.The development of muti-drug resistance in TB causingbacteria, Mycobacterium tuberculosis an… Meer...

Tuberculosis and Cancer are among the mostdevastating and therapeutically challenging diseases.The development of muti-drug resistance in TB causingbacteria, Mycobacterium tuberculosis and cancerouscells has prompted the search for effective novelcompounds. This book focuses on the synthesis and theevaluation of different analogues of diospyrin, aproven anti-TB and anti-cancer agent. A number ofnovel binaphthoquinone and naphthoquinone-naphthalenebiaryl compounds were synthesized by using Suzukimethodology.Several analogues were evaluated for their biologicalactivity against fast growing bacteria viz., M.smegmatis and M. aurum and against a clinical strainof M. tuberculosis. Four novel quinones were alsoevaluated for their ability to induce apoptosis inthree cancer cell lines viz., HeLa, MCF7, MG63 andone normal cell line i.e. CHO by using APOpercentage,DNA fragmentation and Cell cycle assays. Thispreliminary investigation could provoke an interestin scientific community to synthesize otherstructurally modified quinonoids in order to developand establish them as potent drugs againstmycobacterium and cancer. Bücher, Hörbücher & Kalender / Bücher / Sachbuch / Naturwissenschaften / Chemie / Organische Chemie, [PU: VDM Verlag Dr. Müller, Saarbrücken]<

ISBN: 9783639076301

*Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones* - The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones / Taschenbuch für 4… Meer...

*Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones* - The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones / Taschenbuch für 48.99 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (kartoniert) Hardcover;Naturwissenschaften, Medizin, Informatik, Technik;Organische Chemie, VDM Verlag Dr. Müller<

ISBN: 9783639076301

Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones ab 48.99 € als Taschenbuch: The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quin… Meer...

Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones ab 48.99 € als Taschenbuch: The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones. Aus dem Bereich: Bücher, Wissenschaft, Chemie, Medien > Bücher nein Buch (kartoniert) Hardcover;Naturwissenschaften, Medizin, Informatik, Technik;Organische Chemie, VDM Verlag Dr. Müller<