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Activation and Biology, Softcover reprint of hardcover 1st ed. 2003, Softcover, Buch, [PU: Springer]
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Sehgal, P. Levy, D. E. Hirano, T.:
Signal Transducers and Activators of Transcription (STATs) - eerste uitgave2010, ISBN: 9789048164219
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[ED: Kartoniert / Broschiert], [PU: Springer Netherlands], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The only fully comprehensive re… Meer...
2010
ISBN: 9048164214
gebonden uitgave
Softcover reprint of hardcover 1st ed. 2003 Kartoniert / Broschiert Biochemie, Zellbiologie (Zytologie), Translation; Viruses; Vivo; biological functions; conservation; gene expression;… Meer...
2010, ISBN: 9048164214
gebonden uitgave
Softcover reprint of hardcover 1st ed. 2003 Kartoniert / Broschiert Biochemie, Zellbiologie (Zytologie), Translation; Viruses; Vivo; biologicalfunctions; conservation; geneexpression; g… Meer...
2010, ISBN: 9789048164219
gebonden uitgave
Activation and Biology, Softcover reprint of hardcover 1st ed. 2003, Softcover, Buch, [PU: Springer]
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Gedetalleerde informatie over het boek. - Signal Transducers and Activators of Transcription (STATs)
EAN (ISBN-13): 9789048164219
ISBN (ISBN-10): 9048164214
Gebonden uitgave
pocket book
Verschijningsjaar: 2010
Uitgever: Springer
776 Bladzijden
Gewicht: 1,151 kg
Taal: eng/Englisch
Boek bevindt zich in het datenbestand sinds 2011-05-05T10:00:02+02:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2022-05-03T14:16:31+02:00 (Amsterdam)
ISBN/EAN: 9789048164219
ISBN - alternatieve schrijfwijzen:
90-481-6421-4, 978-90-481-6421-9
alternatieve schrijfwijzen en verwante zoekwoorden:
Auteur van het boek: sehgal, david levy, hirano
Titel van het boek: the best signal, activator, stats
Gegevens van de uitgever
Auteur: P. Sehgal; D. E. Levy; T. Hirano
Titel: Signal Transducers and Activators of Transcription (STATs) - Activation and Biology
Uitgeverij: Springer; Springer Netherland
746 Bladzijden
Verschijningsjaar: 2010-12-30
Dordrecht; NL
Gedrukt / Gemaakt in
Taal: Engels
320,99 € (DE)
329,99 € (AT)
354,00 CHF (CH)
POD
XXIV, 746 p. 128 illus., 17 illus. in color.
BC; Hardcover, Softcover / Biologie/Mikrobiologie; Zellbiologie (Zytologie); Verstehen; Activation; Translation; Viruses; Vivo; biological functions; conservation; gene expression; gene transcription; genetics; proteins; regulation; transcription; Cell Biology; Biochemistry; Medical Genetics; Biochemie; Genetik, Medizin; BB
1. Introduction: a brief history of the STATs and a glance at the future.- Section I Stat Proteins and Their Regulators.- 2. The STAT protein family.- 3. The Janus kinase protein family.- 4. Structural bases of receptor-JAK-STAT interactions.- 5. SOCS proteins: negative regulators of the JAK/STAT pathway.- 6. The PIAS protein family and TC-PTP.- 7. Prime time for the Drosophila JAK/STAT pathway.- 8. The STAT proteins of Dictyostelium.- 9. JAK/STATs in zebrafish: conservation of JAK/STAT signaling in vertebrates.- Section II Mechanisms of Activation of and Transcriptional Regulation by Stat Proteins.- 10. IFNs and STATs, an incestuous relationship.- 11. Mechanisms and biological roles of STAT activation by the IL-6 family of cytokines.- 12. Growth hormone induced activation and regulation of JAK2 and STAT proteins.- 13. G protein-coupled-receptor mediated STAT activation.- 14. Regulation of STATs by posttranslational modifications.- 15. Interactions of STATs with SRC family kinases.- 16. The role of phosphatases and reactive oxygen species in regulation of the JAK/STAT pathway.- 17. Raft-STAT signaling and transcytoplasmic trafficking.- 18. Nuclear trafficking of STAT proteins.- 19. Interaction of STAT signals with other signaling pathways.- 20. Forward genetics in mammalian cells.- 21. X-ray crystal structure of STAT proteins and structure-activity relationships.- 22. STAT transcriptional activation mechanisms: communication with the basal transcriptional machinery.- 23. STAT-dependent gene expression without tyrosine phosphorylation.- Section III Biological Impact of Stat Activation.- 24. JAK/STAT signaling: a tale of jeeps and trains.- 25. Viruses and STAT proteins: co-evolution with the JAK-STAT pathway.- 26. STATs in immune responses to viral infections.- 27. IFN, receptor-STAT1 signaling and cancer immunoediting.- 28. STAT activation in TH1/TH2 differentiation.- 29. Mechanisms and biological consequences of STAT signaling by cytokines that share the common cytokine receptor ? chain, ?C 435.- 30. STAT activation in the acute phase response.- 31. STAT3 function in vivo.- 32. Tissue-specific function of STAT3.- 33. Role of STATs in the biological functions of growth hormone.- 34. STAT/SOCS family members in inflammation and diseases.- 35. Signal Transducers and Activators of Transcription in cytokine signaling.- 36. STAT signaling by erythropoietin.- 37. STATs in cell mobility and polarity during morphogenetic movement.- 38. Negative regulators of STAT function in Drosophila.- 39. Jak3 and the pathogenesis of severe combined immunodeficiency.- 40. Constitutively active STATs and cellular transformation.- 41. STAT proteins as molecular targets for cancer therapy.- 42. STATs in the central nervous system.- 43. STATs in the cardiovascular system.- 44. JAKs and STATs as biomarkers of disease.- 45. Drug discovery approaches targeting the JAK/STAT pathway.- Author Index.Includes supplementary material: sn.pub/extras
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