DNA Methylation, Epigenetics and Metastasis - nieuw boek

ISBN: 9789048169177

Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal si… Meer...

Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors "conspire" to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them. In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is now the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio. Books List_Books<

ISBN: 9789048169177

Paperback, [PU: Springer], Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodst… Meer...

Paperback, [PU: Springer], Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors "conspire" to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them. In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is now the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio., Oncology<

2010

ISBN: 9048169178

[EAN: 9789048169177], Neubuch, [PU: Springer Netherlands], PROMOTER GENES MOLECULARMECHANISMS REGULATION TRANSCRIPTION MEDIZIN NICHTKLINISCHE FäCHER DNA MOLECULAR MECHANISMS ONKOLOGIE … Meer...

[EAN: 9789048169177], Neubuch, [PU: Springer Netherlands], PROMOTER GENES MOLECULARMECHANISMS REGULATION TRANSCRIPTION MEDIZIN NICHTKLINISCHE FäCHER DNA MOLECULAR MECHANISMS ONKOLOGIE CANCER RESEARCH MEDICINE ONCOLOGY BIOTECHNOLOGY BIOCHEMISTRY, GENERAL BIOMEDICINE, BIOMEDICAL RESEARC, Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. First description of the epigenetic events involved in metastasis Best experts in the field of DNA methylation in cancer Right combination of theory and applica, Books<

2010, ISBN: 9789048169177

Springer, Taschenbuch, Auflage: Softcover reprint of hardcover 1st ed. 2005, 324 Seiten, Publiziert: 2010-10-22T00:00:01Z, Produktgruppe: Buch, 1.15 kg, Medizin, Kategorien, Bücher, Ingen… Meer...

Springer, Taschenbuch, Auflage: Softcover reprint of hardcover 1st ed. 2005, 324 Seiten, Publiziert: 2010-10-22T00:00:01Z, Produktgruppe: Buch, 1.15 kg, Medizin, Kategorien, Bücher, Ingenieurwissenschaften, Fachbücher, Biotechnologie, Medizin & Gesundheitsdienste, Onkologie, Klinische Medizin, Erkrankungen, Nosologie, Verwaltung & Richtlinien, Ingenieurwissenschaft & Technik, Naturwissenschaften & Technik, Biochemie, Biologie, Biowissenschaften, Genetik, Molekularbiologie, Esteller, Manel, Springer, 2010<

2010, ISBN: 9048169178

gebonden uitgave

Softcover reprint of hardcover 1st ed. 2005 Kartoniert / Broschiert Onkologie, Biochemie, Molekularbiologie, Biotechnologie, Promoter; genes; molecularmechanisms; Regulation; transcript… Meer...

Softcover reprint of hardcover 1st ed. 2005 Kartoniert / Broschiert Onkologie, Biochemie, Molekularbiologie, Biotechnologie, Promoter; genes; molecularmechanisms; Regulation; transcription, mit Schutzumschlag 11, [PU:Springer Netherlands; Springer Netherland]<