ISBN: 9789048176045

In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ''intramembrane-cleaving proteases'' (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer''s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs. Nigel M. Hooper, Books, Health and Well Being, Intramembrane-Cleaving Proteases (I-CLiPs) Books>Health and Well Being, Springer-Verlag/Sci-Tech/Trade

ISBN: 9789048176045

In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ''intramembrane-cleaving proteases'' (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer''s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs. Books List_Books

ISBN: 9789048176045

Authors Nigel M. Hooper and Otto von Guericke, world leaders in protease research, have written the first book that focuses on recent data stemming from the structural determination of intramembrane-cleaving proteases (I-CLiPs). You get the latest findings concerning the various roles that these proteases play in biology and in the course of diseases such as Alzheimer's and viral infection. Books, Science and Geography~~Biology, Life Sciences~~Life Sciences: General Issues, Intramembrane-Cleaving Proteases (i-Clips)~~Book~~9789048176045, , , , , , , , , ,

2010, ISBN: 9048176042

gebonden uitgave

Softcover reprint of hardcover 1st ed. 2007 Kartoniert / Broschiert Pathologie, Zellbiologie (Zytologie), Alzheimer's; Biological Membrane; Cell Signalling; Lipid Metabolism; Protease; Termination; saccharomyces cerevisiae, mit Schutzumschlag neu, [PU:Springer Netherlands; Springer Netherland]

2010, ISBN: 9789048176045

1st ed. Softcover of orig. ed. 2007, Softcover, Buch, [PU: Springer]