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Herausgegeben von Ovádi, Judit Orosz, Ferenc:

Protein folding and misfolding: neurodegenerative diseases - pocketboek

2010, ISBN: 9789048181278

[ED: Softcover], [PU: Springer Netherlands], It was twenty ?ve years ago this year that for the ?rst time a protein under- ing a form of human cerebral amyloidosis, the Icelandic-type her… Meer...

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2009, ISBN: 9789048181278

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Protein folding and misfolding: neurodegenerative diseases als Buch von - gebonden uitgave, pocketboek

2009

ISBN: 9789048181278

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Judit Ovadi; Ferenc Orosz:
Protein folding and misfolding: neurodegenerative diseases - pocketboek

2010, ISBN: 9789048181278

Buch, Softcover, Softcover reprint of hardcover 1st ed. 2009, [PU: Springer], Springer, 2010

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Judit Ovadi; Ferenc Orosz:
Protein folding and misfolding: neurodegenerative diseases - pocketboek

2010, ISBN: 9789048181278

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Softcover reprint of hardcover 1st ed. 2009, Softcover, Buch, [PU: Springer]

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Bijzonderheden over het boek
Protein folding and misfolding: neurodegenerative diseases

The worldwide increasing age of populations brought the neurodegenerative diseases into the focus of interest. A number of the diverse human neurodegenerative diseases are now recognized as conformational diseases frequently caused by aggregations of unfolded or misfolded proteins. Knowledge on the intrinsically unstructured proteins, a new family of gene products as well as on the misfolded proteins produced by genetic mutation or environmental effects has been extensively accumulated in the past years. These proteins frequently cause proteolytic stress and/ or enter into aberrant, non-physiological protein-protein interactions leading to sequestration of protein aggregates which are assemblies of many not-yet-identified components in addition to the deposition of well-characterized misfolded peptides and proteins such as b-amyloid, tau, a-synuclein and polyglutamine containing proteins. These protein assemblies display diverse ultrastructures such aggresomes, fibers, oligomers or amorphous structures, however, the nature of these species concerning their cytoprotective or cytotoxic effects has not been clarified yet.The main focus of this volume is to review the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, with special emphasis on the macromolecular homo- and heteroassociations of the malfolded proteins into characteristic ultrastructures found primarily in Parkinson's and Alzheimer's diseases. This book reviews the structural knowledge accumulated for well-studied and for newly discovered proteins involved in paradigmatic conformational disorders with the aim to broaden our understanding of the pathomechanisms of neurodegeneration, which is crucial for finding effective therapeutic interventions that could prevent or circumvent the development of neurodegenerative disorders in humans.

Gedetalleerde informatie over het boek. - Protein folding and misfolding: neurodegenerative diseases


EAN (ISBN-13): 9789048181278
ISBN (ISBN-10): 9048181275
Gebonden uitgave
pocket book
Verschijningsjaar: 2010
Uitgever: Springer
292 Bladzijden
Gewicht: 0,498 kg
Taal: eng/Englisch

Boek bevindt zich in het datenbestand sinds 2011-03-14T12:37:12+01:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2021-04-10T21:00:06+02:00 (Amsterdam)
ISBN/EAN: 9789048181278

ISBN - alternatieve schrijfwijzen:
90-481-8127-5, 978-90-481-8127-8


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