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Statistics Applied to Clinical Trials - Cleophas, Ton J.; Cleophas, Eugene P.; Cleophas, Toine F.; Zwinderman, A. H.
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Cleophas, Ton J.; Cleophas, Eugene P.; Cleophas, Toine F.; Zwinderman, A. H.:

Statistics Applied to Clinical Trials - pocketboek

2010, ISBN: 904818147X, Lieferbar binnen 4-6 Wochen Verzendingskosten:Versandkostenfrei innerhalb der BRD

Internationaler Buchtitel. In englischer Sprache. Verlag: Springer-Verlag GmbH, Paperback, 584 Seiten, L=235mm, B=155mm, H=31mm, Gew.=871gr, 4. Auflage. [GR: 16930 - HC/Allgemeinmedizin/D… Meer...

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Statistics Applied to Clinical Trials - Ton J. Cleophas, A.H. Zwinderman, Toine F. Cleophas, Eugene P. Cleophas
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Ton J. Cleophas, A.H. Zwinderman, Toine F. Cleophas, Eugene P. Cleophas:

Statistics Applied to Clinical Trials - pocketboek

ISBN: 904818147X

Taschenbuch, [EAN: 9789048181476], Springer, Springer, Book, [PU: Springer], Springer, 65032011, Heilen, 65018011, Alternativmedizin, 64617011, Gesundheit, Geist & Körper, 54071011, Genre… Meer...

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Statistics Applied to Clinical Trials - Cleophas, Ton J. Zwinderman, A. H. Cleophas, Toine F. Cleophas, Eugene P.
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Cleophas, Ton J. Zwinderman, A. H. Cleophas, Toine F. Cleophas, Eugene P.:
Statistics Applied to Clinical Trials - pocketboek

2010

ISBN: 9789048181476

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[ED: Softcover], [PU: Springer Netherlands], This fourth edition has been updated and extended to serve as a more complete guide and reference for students, physicians, and investigators,… Meer...

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Statistics Applied to Clinical Trials

The previous three editions of this book, rather than having been comprehensive, concentrated on the most relevant aspects of statistical analysis. Although well-received by students, clinicians, and researchers, these editions did not answer all of their questions. This updated and extended edition has been written to serve as a more complete guide and reference-text to students, physicians, and investigators, and, at the same time, preserves the common sense approach to statistical problem-solving of the previous editions. In 1948 the first randomized controlled trial was published by the English Medical Research Council in the British Medical Journal. Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to little sensitivity due to small samples, as well as inappropriate hypotheses based on biased prior trials. Additional flaws were being recognized and, subsequently were better accounted for: carryover effects due to insufficient washout from previous treatments, time effects due to external factors and the natural history of the condition under study, bias due to asymmetry between treatment groups, lack of sensitivity due to a negative correlation between treatment responses etc. Such flaws mainly of a technical nature have been largely implemented and lead to trials after 1970 being of significantly better quality than before. The past decade focused, in addition to technical aspects, on the need for circumspection in planning and conducting of clinical trials. As a consequence, prior to approval, clinical trial protocols are now routinely scrutinized by different circumstantial organs, including ethic committees, institutional and federal review boards, national and international scientific organizations, and monitoring committees charged with conducting interim analyses. The present book not only explains classical statistical analyses of clinical trials, but also addresses relatively novel issues, including equivalence testing, interim analyses, sequential analyses, meta-analyses, and provides a framework of the best statistical methods currently available for such purpose. This book is not only useful for investigators involved in the field of clinical trials, but also for students and physicians who wish to better understand the data of trials as published currently.

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EAN (ISBN-13): 9789048181476
ISBN (ISBN-10): 904818147X
Gebonden uitgave
pocket book
Verschijningsjaar: 2010
Uitgever: Springer-Verlag GmbH
584 Bladzijden
Gewicht: 0,871 kg
Taal: eng/Englisch

Boek bevindt zich in het datenbestand sinds 2011-11-06T07:05:25+01:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2014-02-27T15:06:00+01:00 (Amsterdam)
ISBN/EAN: 9789048181476

ISBN - alternatieve schrijfwijzen:
90-481-8147-X, 978-90-481-8147-6


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