ISBN: 9789048181568
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2010, ISBN: 9048181569
[EAN: 9789048181568], Nieuw boek, [SC: 13.94], [PU: Springer Netherlands], MONOCLONALANTIBODIES; TISSUE; TRANSPLANTATION; TUMORGROWTH, Besorgungstitel Neuware - Rare Book Procurement - In… Meer...
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In 1971, J. Folkman published in the â??New England Journal of Medicineâ? a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably se… Meer...
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2004, ISBN: 9789048181568
In 1971, J. Folkman published in the "New England Journal of Medicine" a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors proba… Meer...
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2010, ISBN: 9789048181568
auteur: Ribatti, Domenico, Springer, Paperback, Auflage: Softcover reprint of hardcover 1st ed. 2009, 136 Seiten, Publiziert: 2010-10-19T00:00:01Z, Produktgruppe: Book, Hersteller-Nr.: bi… Meer...
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ISBN: 9789048181568
History of Research on Tumor Angiogenesis Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days).Author(s): Dom… Meer...
2010, ISBN: 9048181569
[EAN: 9789048181568], Nieuw boek, [SC: 13.94], [PU: Springer Netherlands], MONOCLONALANTIBODIES; TISSUE; TRANSPLANTATION; TUMORGROWTH, Besorgungstitel Neuware - Rare Book Procurement - In… Meer...
2004
ISBN: 9789048181568
In 1971, J. Folkman published in the â??New England Journal of Medicineâ? a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably se… Meer...
2004, ISBN: 9789048181568
In 1971, J. Folkman published in the "New England Journal of Medicine" a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors proba… Meer...
2010, ISBN: 9789048181568
auteur: Ribatti, Domenico, Springer, Paperback, Auflage: Softcover reprint of hardcover 1st ed. 2009, 136 Seiten, Publiziert: 2010-10-19T00:00:01Z, Produktgruppe: Book, Hersteller-Nr.: bi… Meer...
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Gedetalleerde informatie over het boek. - History of Research on Tumor Angiogenesis
EAN (ISBN-13): 9789048181568
ISBN (ISBN-10): 9048181569
Gebonden uitgave
pocket book
Verschijningsjaar: 2010
Uitgever: Springer
136 Bladzijden
Gewicht: 0,217 kg
Taal: eng/Englisch
Boek bevindt zich in het datenbestand sinds 2012-02-28T12:56:35+01:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2023-07-03T23:56:53+02:00 (Amsterdam)
ISBN/EAN: 9789048181568
ISBN - alternatieve schrijfwijzen:
90-481-8156-9, 978-90-481-8156-8
alternatieve schrijfwijzen en verwante zoekwoorden:
Auteur van het boek: domenico
Titel van het boek: tumor, history
Gegevens van de uitgever
Auteur: Domenico Ribatti
Titel: History of Research on Tumor Angiogenesis
Uitgeverij: Springer; Springer Netherland
126 Bladzijden
Verschijningsjaar: 2010-10-19
Dordrecht; NL
Gedrukt / Gemaakt in
Taal: Engels
160,49 € (DE)
164,99 € (AT)
177,00 CHF (CH)
POD
X, 126 p.
BC; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Onkologie; Verstehen; Monoclonal Antibodies; angiogenesis; tissue; transplantation; tumor growth; Cancer Biology; Oncology; History of Science; Pathology; Cell Biology; Geschichte der Naturwissenschaften; Pathologie; Zellbiologie (Zytologie); BB; EA
In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis.
Beginning in the 1980’s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy.
This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.
1: 1.1 Early evidence of the vascular phase and its importance in tumor growth. 1.2 Early evidence of tumor cells releasing specific growth factors for blood vessels. 1.3 Tumors in isolated perfused organs: absence of angiogenesis. 1.4 The avascular and the vascular phases of solid tumor growth. 2: 2.1 Isolation of the first angiogenic tumor factor. 2.2 The discovery of basic fibroblast growth factor/fibroblast growth factor-2. 2.3 The discovery of vascular permeability factor/vascular endothelial growth factor. 2.4 The discovery of angiopoietins. 3: 3.1 How do tumor cells switch to the angiogenic phenotype ? 3.2 The concept of angiogenic switch. 3.3 Factors involved in the angiogenic switch. 3.4 What is the evidence that genetic instability promotes the angiogenic switch ? 4: 4.1 Tumor endothelial cells features. 4.2 Tumor basement membrane. 4.3 Tumor pericytes. 5: 5.1 Tumor lymphangiogenesis. 6: 6.1 The contribution of inflammatory cells to tumor angiogenesis. 7: 7.1 The role of endothelial progenitor cells in tumor angiogenesis. The first isolation of putative endothelial progenitor cells. 7.2 Characterization of endothelia progenitor cells. 7.3 Triggers and inhibitors of endothelial progenitor cells to sites of active neovascularisation. 7.4 The transplantation models to study endothelial progenitor cells. 7.5 The identification of bone marrow-derived multipotent progenitor cells. 7.6 Monocyte/macrophage as a source of endothelial progenitor cells. 7.7 Contribution of endothelial progenitor cells to tumor angiogenesis. 8: 8.1 Tumor microvascular density as a prognostic indicator. 8.2 Use of panendothelial cell markers. 8.3 Topography. 8.4 Certain human tumor types can exhibit lower microvascular density that the corresponding normal tissues. 8.5 Prognostic value of microvascular density. 8.6 The relationship between microvascular density and intercapillary distance. 9: 9.1 Inhibitors of angiogenesis. 9.2 Metronomic chemotherapy. 9.3 Receptor tyrosine kinase (RTK) inhibitors. 9.4 Inhibitors of VEGF. 9.5 Antiangiogenic monoclonal antibodies: towards the discovery of Avastin. 9.6 Microvascular density has not been shown to be a valid measurement to guide or evaluate antiangiogenic treatment. 9.7. Perspectives. References.
In 1971, J. Folkman published in the "New England Journal of Medicine" a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis.
Beginning in the 1980's, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy.
This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.
Andere boeken die eventueel grote overeenkomsten met dit boek kunnen hebben:
Laatste soortgelijke boek:
9781402095634 History of Research on Tumor Angiogenesis (Domenico Ribatti)
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