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Pnina Brodt:
Liver Metastasis: Biology and Clinical Management (Cancer Metastasis - Biology and Treatment) - gebonden uitgave, pocketboek

2011, ISBN: 9400702914

[SR: 5827494], Hardcover, [EAN: 9789400702912], Springer, Springer, Book, [PU: Springer], 2011-03-04, Springer, Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches, 270852, Immunology, 270847, Diseases & Disorders, 270842, Internal Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 270860, Oncology, 270847, Diseases & Disorders, 270842, Internal Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 270930, Medical Imaging, 270906, Other Branches of Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 922816, Radiology, 922610, Diseases & Disorders, 922532, Medicine, 57, Science & Nature, 1025612, Subjects, 266239, Books, 922730, Radiology & Medical Imaging, 922572, Medical Sciences A-Z, 922532, Medicine, 57, Science & Nature, 1025612, Subjects, 266239, Books, 270792, Basic Medical Science, 270793, Anatomy, 270807, Medical Genetics, 270808, Physiology, 564356, Medicine & Nursing, 564334, Scientific, Technical & Medical, 1025612, Subjects, 266239, Books, 571350, Radiology & Medical Imaging, 571382, Medical Sciences A-Z, 564356, Medicine & Nursing, 564334, Scientific, Technical & Medical, 1025612, Subjects, 266239, Books

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Springer:
Liver Metastasis: Biology and Clinical Management - nieuw boek

2011, ISBN: 9789400702912

ID: 812816731

Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology. Despite recent advances in surgery, and more aggressive resection, liver metastases still prove fatal in a high proportion of cases. This volume aims to enhance our understanding of the biology of hepatic cancer metastasis, in particular its early stages. Buch (fremdspr.) gebundene Ausgabe 04.03.2011 Bücher>Fremdsprachige Bücher>Englische Bücher, Springer, .201

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Pnina Brodt:
Liver Metastasis: Biology and Clinical Management - nieuw boek

ISBN: 9789400702912

[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic m, Neuware, gewerbliches Angebot, FixedPrice, [GW: 804g]

(*)

Pnina Brodt:
Liver Metastasis: Biology and Clinical Management - nieuw boek

ISBN: 9789400702912

ID: 9789400702912

Biomedicine; Cancer Research; Oncology; Surgical Oncology; Imaging / Radiology; Immunology Breast cancer, Cancer and Inflammation, Colon cancer, Liver metastasis, Liver microenvironment Books Book, Springer Science+Business Media

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Brodt, Pnina:
Liver Metastasis: Biology and Clinical Management - gebonden uitgave, pocketboek

2011, ISBN: 9789400702912

[ED: Gebunden], [PU: Springer Netherland], DE, [SC: 0.00], Neuware, gewerbliches Angebot, 446, [GW: 804g], PayPal