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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid: Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids - Barun Majumder
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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid: Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids - pocketboek

2011, ISBN: 9783845409184

Paperback, [EAN: 9783845409184], LAP LAMBERT Academic Publishing, LAP LAMBERT Academic Publishing, Book, [PU: LAP LAMBERT Academic Publishing], 2011-08-01, LAP LAMBERT Academic Publishing… Meer...

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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid: Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids - pocketboek

ISBN: 9783845409184

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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid: Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids - pocketboek

2011

ISBN: 9783845409184

LAP LAMBERT Academic Publishing, 2011-08-01. Paperback. Good., LAP LAMBERT Academic Publishing, 2011-08-01

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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids - Majumder, Barun
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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids - nieuw boek

2011, ISBN: 3845409185

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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid: Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids - pocketboek

2011, ISBN: 3845409185

[EAN: 9783845409184], [PU: LAP LAMBERT Academic Publishing], Books

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Modulation of Breast Cancer Genes by Conjugated Linoleic Acid: Modulation of Genes Involved in the Apoptotic Pathway in Human Breast Cancer by Conjugated Linoleic Acid and Fatty Acids
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ISBN:

3845409185


Dietary Eicosapentaenoic Acid (EPA), Conjugated Linoleic Acid (CLA) and Oleic Acid (OA) have been postulated to reduce the risk of breast cancer. This study has examined the effects of these dietary fatty acids on the induction of apoptosis in normal breast epithelial (MCF-10A), oestrogen receptor positive (MCF-7) and oestrogen receptor negative breast cancer cells (MDA-MB-231).Cell proliferation was assessed using the MTT assay, and the comet assay was used to examine the extent of DNA damage (as a marker of apoptosis). Changes in the expression of mRNA and the proteins of the major pro-apoptotic P53, p21WAF1/CIP1, BAX, BCL-XS genes and the anti-apoptotic BCL-2 gene were determined in these cell lines in vitro. The greatest cell growth inhibition and induction of apoptosis was observed after exposure to CLA. Further investigations focussed on the mechanisms underlying the anti-tumour effects of CLA. CLA increased P53 and p21WAF1/CIP1 mRNA expression (3-5-fold and 2-fold respectively) and decreased BCL-2 by 20-30%. Protein expression reflected the changes in mRNA expression.

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EAN (ISBN-13): 9783845409184
ISBN (ISBN-10): 3845409185
Gebonden uitgave
pocket book
Verschijningsjaar: 2011
Uitgever: LAP Lambert Acad. Publ. Aug 2011

Boek bevindt zich in het datenbestand sinds 2008-12-08T11:10:44+01:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2018-10-16T00:18:51+02:00 (Amsterdam)
ISBN/EAN: 3845409185

ISBN - alternatieve schrijfwijzen:
3-8454-0918-5, 978-3-8454-0918-4
alternatieve schrijfwijzen en verwante zoekwoorden:
Titel van het boek: genes, human breast cancer, conjugated linoleic acid, conjugated linoleic acids

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