2010, ISBN: 9783527658923

Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneerin… Meer...

Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneering contributions to the field. The coming of age of this active area of research is showcased in this book through case studies in which process chemists from the pharmaceutical industry share their personal experiences developing their own transition metal-catalyzed couplings for the large-scale manufacture of active pharmaceutical ingredients. Authors from Pfizer, Merck, Boehringer-Ingelheim, Novartis, Amgen, GSK, AstraZeneca, and other companies describe the evolution of robust coupling processes from inception through early and late development, including commercial routes where applicable. This book covers a wide range of coupling transformations while capturing the lessons learned from each process. Every case study details the optimization of at least one transition metal-catalyzed coupling while elaborating on issues such as design of experiments, scalability and throughput, product purification, process safety, and waste management. The important issue of metal removal and the different technologies available to accomplish this goal are also addressed. Finally, a section covers novel technologies for cross-coupling with high potential for future applications on a large scale, such as microwave and flow chemistry as well as green cross-couplings performed in water. With Forewords by Stephen L. Buchwald, Massachusetts Institute of Technology, Trevor Laird, Editor of Organic Process Research and Development and Neal G. Anderson, Anderson's Process Solutions LLC.; PDF; Scientific, Technical and Medical > Chemistry, Springer Berlin Heidelberg<

2010, ISBN: 9783527658923

Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneerin… Meer...

Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneering contributions to the field. The coming of age of this active area of research is showcased in this book through case studies in which process chemists from the pharmaceutical industry share their personal experiences developing their own transition metal-catalyzed couplings for the large-scale manufacture of active pharmaceutical ingredients. Authors from Pfizer, Merck, Boehringer-Ingelheim, Novartis, Amgen, GSK, AstraZeneca, and other companies describe the evolution of robust coupling processes from inception through early and late development, including commercial routes where applicable. This book covers a wide range of coupling transformations while capturing the lessons learned from each process. Every case study details the optimization of at least one transition metal-catalyzed coupling while elaborating on issues such as design of experiments, scalability and throughput, product purification, process safety, and waste management. The important issue of metal removal and the different technologies available to accomplish this goal are also addressed. Finally, a section covers novel technologies for cross-coupling with high potential for future applications on a large scale, such as microwave and flow chemistry as well as green cross-couplings performed in water. With Forewords by Stephen L. Buchwald, Massachusetts Institute of Technology, Trevor Laird, Editor of Organic Process Research and Development and Neal G. Anderson, Anderson's Process Solutions LLC. Digital Content>E-books>Science>Engineering>Chemical Engr, Wiley Digital >16<

ISBN: 9783527658923

Wiley-VCH Industrial & Technical Chemistry reactions; rich; metalcatalyzed; nobel; chemistry; awarding; prize; history; negishi; field; contributions; case; area; age; book; active; resea… Meer...

Wiley-VCH Industrial & Technical Chemistry reactions; rich; metalcatalyzed; nobel; chemistry; awarding; prize; history; negishi; field; contributions; case; area; age; book; active; research; studies; pfizer; robust; evolution; companies; inception; coupling processes; routes; commercial , UK,GB,DE,ES,FR,IT,US,CA,MX,AU,NZ 20130703 English Physical Sciences 1, Wiley<

ISBN: 9783527658923

*Transition Metal-Catalyzed Couplings in Process Chemistry* - Case Studies from the Pharmaceutical Industry. 1. Auflage / epub eBook für 153.99 € / Aus dem Bereich: eBooks, Fachthemen & W… Meer...

*Transition Metal-Catalyzed Couplings in Process Chemistry* - Case Studies from the Pharmaceutical Industry. 1. Auflage / epub eBook für 153.99 € / Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Wissenschaften, allgemein Medien > Bücher nein eBook als epub eBooks > Fachthemen & Wissenschaft > Wissenschaften allgemein, Wiley-VCH<

ISBN: 9783527658923

Transition Metal-Catalyzed Couplings in Process Chemistry - Case Studies from the Pharmaceutical Industry. 1. Auflage: ab 153.99 € eBooks > Fachthemen & Wissenschaft > Wissenschaften allg… Meer...

Transition Metal-Catalyzed Couplings in Process Chemistry - Case Studies from the Pharmaceutical Industry. 1. Auflage: ab 153.99 € eBooks > Fachthemen & Wissenschaft > Wissenschaften allgemein Wiley-VCH eBook als epub, Wiley-VCH<