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ISBN: 9783642386640

This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this … Meer...

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Pharmacotherapy of Pulmonary Hypertension - nieuw boek

ISBN: 9783642386640

This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this … Meer...

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Springer:
Pharmacotherapy of Pulmonary Hypertension - nieuw boek

2013

ISBN: 9783642386640

This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this … Meer...

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Pharmacotherapy of Pulmonary Hypertension - nieuw boek

ISBN: 9783642386640

This book focuses on current, evidence-based pharmacological treatments of various forms of pulmonary hypertension and also provides a comprehensive review of recent developments in this … Meer...

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Marc Humbert; Oleg V. Evgenov; Johannes-Peter Stasch:
Pharmacotherapy of Pulmonary Hypertension - nieuw boek

2013, ISBN: 9783642386640

eBooks, eBook Download (PDF), 2013, [PU: Springer Berlin], Springer Berlin, 2013

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Pharmacotherapy of Pulmonary Hypertension
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9783642386640

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EAN (ISBN-13): 9783642386640
ISBN (ISBN-10): 3642386644
Verschijningsjaar: 2013
Uitgever: Springer Berlin
576 Bladzijden
Taal: eng/Englisch

Boek bevindt zich in het datenbestand sinds 2012-03-01T01:35:45+01:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2022-08-31T08:52:56+02:00 (Amsterdam)
ISBN/EAN: 9783642386640

ISBN - alternatieve schrijfwijzen:
3-642-38664-4, 978-3-642-38664-0
alternatieve schrijfwijzen en verwante zoekwoorden:
Auteur van het boek: johannes peter, humbert, stasch, johann peter, hum, stas peter, staß, marc peter
Titel van het boek: hype, hypertension

Gegevens van de uitgever

Auteur: Marc Humbert; Oleg V. Evgenov; Johannes-Peter Stasch
Titel: Handbook of Experimental Pharmacology; Pharmacotherapy of Pulmonary Hypertension
Uitgeverij: Springer; Springer Berlin
576 Bladzijden
Verschijningsjaar: 2013-10-04
Berlin; Heidelberg; DE
Gedrukt / Gemaakt in
Taal: Engels
Available
IX, 576 p. 66 illus., 56 illus. in color.

EA; E107; eBook; Nonbooks, PBS / Medizin/Pharmazie; Pharmakologie; Verstehen; Vasoactive substances; WHO Group I-V; lung vasculature; pulmonary artery; pulmonary hypertension (PH); pulmonary vein; C; Pharmacology/Toxicology; Pharmaceutical Sciences/Technology; Internal Medicine; Pneumology/Respiratory System; Laboratory Medicine; Molecular Medicine; Pharmacology; Pharmaceutics; Internal Medicine; Pneumology; Biomedical Research; Biomedical and Life Sciences; Medizinische Chemie, Pharmazeutische Chemie; Klinische und Innere Medizin; Lungen- und Bronchialheilkunde; Medizinische Forschung; BB

Over the past decade, major advancements in the understanding of the molecular mechanisms and pathophysiology of pulmonary hypertension occurred in parallel with the discovery and development of new therapies. Pharmacological agents that modulate the main pathophysiological pathways of pulmonary arterial hypertension have changed the course of this devastating disease by relieving symptoms and improving and prolonging patients’ lives.

The first part of the book covers definition, classification, pathophysiology, pathology, biomarkers and animal models of pulmonary hypertension, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The concluding section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotides homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to clinical applications of these experimental therapies.

Preface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models.- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors.- Part III. Pulmonary hypertension: novel pathways and emerging therapies     Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy.- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.

Written by leading experts in the field of pulmonary hypertension

Broadens your understanding of current, evidence-based pharmacological treatments of various forms of pulmonary hypertension

Comprehensive review of most recent developments in this field including new signaling pathways

Includes supplementary material: sn.pub/extras


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