2007, ISBN: 9781402065613

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists inve… Meer...

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few 'mad' scientists searching for 'natural' substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research. TOC:Preface.- Introduction.- Paraoxonases: An Historical Perspective. The Bert La Du Memorial Lecture.- PONs and Atherosclerosis.- Glucose- induced inactivation of HDL associated paraoxonase 1 (PON1) and its relevance to diabetes.- Paraoxonase 1 and Cardiovascular Disease.- The relationship between PON1 activity and oxidative stress.- D-4F Increases Paraoxonase 1 activity.- Paraoxonase 1 (PON1): A junction between the metabolism of homocysteine and lipids.- The role of PON2 and PON3 in atherosclerosis and related traits.- PON1 and postprandial lipaemia.- PON genes and atherosclerosis.- PON1 Structure.- Structure of human serum PON1.- Requirements for stable active form of natural human PON1.- PONs in Disease other than Atherosclerosis.- Paraoxonase- 1 in chronic liver disease and HIV infection.- Age related alterations in PON1.- PON in Neurological Disorders.- PON and Toxicology.- Paraoxonase (PON1) and organophosphate toxicity.- Influence of paraoxonase polymorphisms on biochemical and clinical outcomes in humans occupationally exposed to pesticides.- PON-Genetics and Regulation.- Transcriptional regulation of the paraoxonase genes.- Effect of lipid lowering medication on PON1.- The functional consequences of polymorphisms in the PON1 gene.- Dietary modulation of paraoxonase-1 activity and concentration in humans.- PONs Biochemistry.- Natural substrates for PONs - the key for their physiological activity.- PONs and Quorum eBook Springer PDF, Springer, 26.10.2007, Springer, 2007<

2007, ISBN: 9781402065613

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists inve… Meer...

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few 'mad' scientists searching for 'natural' substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research. TOC:Preface.- Introduction.- Paraoxonases: An Historical Perspective. The Bert La Du Memorial Lecture.- PONs and Atherosclerosis.- Glucose- induced inactivation of HDL associated paraoxonase 1 (PON1) and its relevance to diabetes.- Paraoxonase 1 and Cardiovascular Disease.- The relationship between PON1 activity and oxidative stress.- D-4F Increases Paraoxonase 1 activity.- Paraoxonase 1 (PON1): A junction between the metabolism of homocysteine and lipids.- The role of PON2 and PON3 in atherosclerosis and related traits.- PON1 and postprandial lipaemia.- PON genes and atherosclerosis.- PON1 Structure.- Structure of human serum PON1.- Requirements for stable active form of natural human PON1.- PONs in Disease other than Atherosclerosis.- Paraoxonase- 1 in chronic liver disease and HIV infection.- Age related alterations in PON1.- PON in Neurological Disorders.- PON and Toxicology.- Paraoxonase (PON1) and organophosphate toxicity.- Influence of paraoxonase polymorphisms on biochemical and clinical outcomes in humans occupationally exposed to pesticides.- PON-Genetics and Regulation.- Transcriptional regulation of the paraoxonase genes.- Effect of lipid lowering medication on PON1.- The functional consequences of polymorphisms in the PON1 gene.- Dietary modulation of paraoxonase-1 activity and concentration in humans.- PONs Biochemistry.- Natural substrates for PONs - the key for their physiological activity.- PONs and Quorum eBook PDF, Springer, 26.10.2007, Springer, 2007<

2007, ISBN: 9781402065613

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists inve… Meer...

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few 'mad' scientists searching for 'natural' substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research. TOC:Preface.- Introduction.- Paraoxonases: An Historical Perspective. The Bert La Du Memorial Lecture.- PONs and Atherosclerosis.- Glucose- induced inactivation of HDL associated paraoxonase 1 (PON1) and its relevance to diabetes.- Paraoxonase 1 and Cardiovascular Disease.- The relationship between PON1 activity and oxidative stress.- D-4F Increases Paraoxonase 1 activity.- Paraoxonase 1 (PON1): A junction between the metabolism of homocysteine and lipids.- The role of PON2 and PON3 in atherosclerosis and related traits.- PON1 and postprandial lipaemia.- PON genes and atherosclerosis.- PON1 Structure.- Structure of human serum PON1.- Requirements for stable active form of natural human PON1.- PONs in Disease other than Atherosclerosis.- Paraoxonase- 1 in chronic liver disease and HIV infection.- Age related alterations in PON1.- PON in Neurological Disorders.- PON and Toxicology.- Paraoxonase (PON1) and organophosphate toxicity.- Influence of paraoxonase polymorphisms on biochemical and clinical outcomes in humans occupationally exposed to pesticides.- PON-Genetics and Regulation.- Transcriptional regulation of the paraoxonase genes.- Effect of lipid lowering medication on PON1.- The functional consequences of polymorphisms in the PON1 gene.- Dietary modulation of paraoxonase-1 activity and concentration in humans.- PONs Biochemistry.- Natural substrates for PONs - the key for their physiological activity.- PONs and Quorum eBook Springer 26.10.2007, Springer, Springer<

2007, ISBN: 9781402065613

eBooks, eBook Download (PDF), 2008, [PU: Springer Netherland], Springer Netherland, 2007

ISBN: 9781402065613

; PDF; Scientific, Technical and Medical > Clinical & internal medicine > Diseases & disorders, Raintree UK