2010, ISBN: 9789048195312

Chronic inflammation is one of the major pathological bases manifesting the development of gastric cancers, hepatitis and hepatocellular carcinoma, cervical cancer, ulcerative colitis and… Meer...

Chronic inflammation is one of the major pathological bases manifesting the development of gastric cancers, hepatitis and hepatocellular carcinoma, cervical cancer, ulcerative colitis and colorectal cancer [1]. Microbial infections, viral infections and autoimmune responses can lead to chronic inflammation-associated cancer formation. Human herpesviruses, such as human cytomegalovirus (HCMV) and Kaposi sarcoma herpesvirus (KSHV) are known to be associated with tumorigenesis and tumor progression. HCMV infection potentiates malignancies of colon cancer and malignant glioma [2,3]. KSHV was initially discovered from Kaposi's sarcoma lesion of an AIDS patient [4]. It was subsequently discovered that KSHV contributed to the pathogenesis of KS, primary effusion lymphoma [5] and lymphoproliferative disorder multicentric Castleman's disease. Emerging evidence shows that herpesvirus infection interferes or inhibits host cell immune defense and maintains a tumor-promoting microenvironment by expressing virulent homologues of host cell proteins that disturb normal cell cycle progression and leads to apoptosis of the host cells. For example, cellular growth and transformation are induced by viral-encoded homologues of cytokines, chemokines or chemokine receptors [6]. The constitutive expression of viral chemokine GPCRs triggers prolonged activation of G protein signaling and eventually becomes the major inputs for chronic leukocyte infiltration and cancer development. GPCRs can serve as proto-oncogenes since overexpression of various wild type GPCRs can transform cells in the presence of their specific ligands. Mutations on GPCRs may result in constitutive signaling and oncogenesis [7]. Naturally occurring mutations in GPCRs have been identified in human tumors [8,9]. eBook Springer 09.09.2010, Springer, Springer<

ISBN: 9789048195312

The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading … Meer...

The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away―in a scientifically accessible manner―from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: • First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, • then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and • finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions). Digital Content>E-books>Medicine>Medical Ref>Spec Procedure, Springer Netherlands Digital >16<

ISBN: 9789048195312

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease.Reader… Meer...

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease.Readers will find ways to record tumor biology that are based on different sciences, in addition to other strategies.; PDF; Scientific, Technical and Medical > Medicine: general issues, World Scientific Publishing Company<

ISBN: 9789048195312

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease. Reade… Meer...

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease. Readers will find ways to record tumor biology that are based on Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease. Readers will find ways to record tumor biology that are based on, Springer<

2010, ISBN: 9789048195312

Tumors are Reconstructible Communicatively Evolving Systems, eBooks, eBook Download (PDF), Auflage, [PU: Springer-Verlag], [ED: 1], Springer-Verlag, 2010