Drug Metabolism: Current Concepts - pocketboek

Boek bevindt zich in het datenbestand sinds 2010-04-16T13:59:10+02:00 (Amsterdam)
Detailpagina laatst gewijzigd op 2022-06-09T11:03:02+02:00 (Amsterdam)
ISBN/EAN: 9789048170586

ISBN - alternatieve schrijfwijzen:
90-481-7058-3, 978-90-481-7058-6

Gegevens van de uitgever

Auteur: Mino R. Caira; Corina Ionescu
Titel: Drug Metabolism - Current Concepts
Uitgeverij: Springer; Springer Netherland
422 Bladzijden
Verschijningsjaar: 2010-11-06
Dordrecht; NL
Gedrukt / Gemaakt in
Gewicht: 0,692 kg
Taal: Engels
219,98 € (DE)
226,15 € (AT)
242,50 CHF (CH)
POD
XIV, 422 p.

BC; Previously published in hardcover; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Medizinische Forschung; Verstehen; Oxidation; adverse reactions; biochemistry; chemistry; distribution; drug; drug research; genetics; hydrolysis; medicinal chemistry; metabolism; pharmacokinetics; pharmacology; pharmacy; research; B; Biomedicine, general; Pharmacy; Medicinal Chemistry; Pharmacology/Toxicology; Molecular Medicine; Biomedical Research; Pharmacy; Medicinal Chemistry; Pharmacology; Biomedical and Life Sciences; Pharmazie, Apotheke; Medizinische Chemie, Pharmazeutische Chemie; Pharmakologie; BB

provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Drug Metabolism In Context: Introduction.- Absorption.- Drug Distribution.- Dynamics Of Drug Action.- 5 Drug Clearance.- Dynamics Of Drug Clearance.- Pathways Of Biotransformation – Phase I Reactions: Introduction.- Phase I And Phase II Metabolism: General Considerations.- Oxidations Involving The Microsomal Mixed-Function Oxidase System.- Oxidations Involving Other Enzymatic Systems.- Metabolic Reactions Involving Reduction.- Hydrolysis.- Miscellanous Phase I Reactions.- The Fate Of Phase I Reaction Products.- Pathways Of Biotransformation – Phase II Reactions: Introduction.- Glucuronidation.- Acetylation.- Glutathione Conjugation.- Other Conjugative Reactions.- Concluding Remarks.- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction.- Interaction Between A Drug Substrate And An Enzyme.- Enzyme Systems With Specific Roles.- Final Remarks.- Induction And Inhibition Of Drug-Metabolising Enzymes.- Introduction.- Induction.- Inhibition.- Consequences Of The Above Phenomena.- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition.- Factors That Influence Drug Biotransformation.- Introduction.- Intrinsic Factors.- Environmental Factors.- Further Observations.- Impact Of Gene Variability On Drug Metabolism.- Introduction.- Basic Principles Of Pharmacogenetics.- Pharmaco-Informatics.- Implications For Third Millennium Medicine.- Drug Interactions And Adverse Reactions: Introduction.- Drug-Drug Interactions.- Interactions Between Drugs And Other Entities.- Adverse Reactions.- Summary.- Strategies For Drug Design.- Introduction.- Pharmacokinetics And Metabolism In Drug Research.- The Role Of Formulation.- Concluding Remarks.- Index.

Includes an extensive tabulation of drug-drug interactions and a section dealing with the relatively new topic of pharmacogenetics, as it relates to drug metabolism.

Emphasises the importance of metabolism throughout the lifetime of the drug development process, bringing together chemical design and optimisation with eventual clinical use.

Includes many more types of metabolic reactions and interactions than existing publications.

An emphasis on the understanding of the topics at the molecular level.

Avoids details of chemical methodology, allowing the reader to focus on the concepts underlying drug delivery optimisation through a knowledge of the principles of biotransformation.

Provides a new, detailed and accessible presentation of drug-drug interactions and adverse reactions at the molecular level.

Systematically outlines modern strategies in drug design based primarily on metabolic considerations.

The treatment of drug design is more comprehensive than previous coverage as it covers all aspects and implications of drug metabolism the authors consider relevant to the target